Bargues the epidemiological picture of human fascioliasis has changed in recent years. S1 and fasciola gigantica from nepal lc061154 in fig. Resistance of fasciola hepatica against triclabendazole in. Foodborne trematodiases are a group of neglected tropical diseases caused by liver, lung, and intestinal parasitic fluke infections. Impact of human activities on fasciolosis transmission. Fasciola hepatica has recently emerged as a major pathogen of humans from reports on areas of endemicity and hyperendemicity for fascioliasis. This parasite liver fluke is endemic in many parts of the world including countries from asia, africa, europe and the americas. Hyperendemicity of human fasciolosis in the mantaro valley, peru. Author summary fascioliasis is a neglected infectious disease caused by the trematode fasciola. Bioclimatic distribution and prevalence maps for fasciola. Fasciola hepatica phenotypic characterization in andean.
The number of reports of humans infected with fasciola hepatica has increased significantly since 1980 and several geographical areas have been. The cows were treated with nitroxynil in may and september prior to calving and with ivermectin after calving. Zoonotic helminth infections with particular emphasis on. The 37 pepck genotypes of the 27 fasciola flukes from spain analyzed in this study. A map was created based on analysis of epidemiological data. This report concerns the identification and clinical management of cases of human fascioliasis in the suburbs of arusha city, northern tanzania in 20.
Zoonotic trematode infections are an area of the neglected tropical diseases that have become of major interest to global and public health due to their associated morbidity. It is currently reemerging in several regions mainly due to the rapid evolution of human activities. Fasciolosis caused by fasciola hepatica severely affects the efficiency of livestock production systems worldwide. Fasciolosis also known as fascioliasis, fasciolasis, distomatosis and liver rot is a parasitic worm infection caused by the common liver fluke fasciola hepatica as well as by fasciola gigantica. Identification, causes and control publishing london 22 305. The status of human and animal fascioliasis in iran. Our laboratory has developed an enzymelinked immunosorbent assay fas2elisa based on the capture of igg. Liver, spleen, pancreas and kidney involvement by human. Tegument glycoproteins and cathepsins of newly excysted. Diagnosis of soiltransmitted helminthiasis in an amazonic. In order to help develop a control strategy for liver fluke, a risk factor study of farm management factors was conducted and the utility of bulk tank milk btm elisa as a tool for diagnosis in danish dairy cattle farms was assessed. The disease progresses through four distinct phases.
Comparative diagnosis of serum igg1 and coproantigen elisa. Fas2elisa in the detection of human infection by fasciola. Several outbreaks of this disease recently occurred in the gilan province of northern iran and in. Fasciolosis, or liver fluke disease, caused by parasites of the genus fasciola is emerging as an important disease in man, particularly in countries such as bolivia, peru and egypt. A total of 1070 serum and faecal samples were analyzed for igg1 antibodies and coproantigens, using elisa with es products as antigen and a monoclonal antibodybased sandwich elisa. The infection has an annual cycle, with the major period of infection from january to march. Fasciolosis affects different ruminant species and leads to great economic losses for cattle farmers worldwide. The disease is a wellknown veterinary problem of worldwide distribution.
Here we report a known case of multiple myeloma who was under treatment with prednisolone and melphalan. The mode of action of tcbz and mechanisms underlying parasite resistance to the drug are not known. Fascioliasis, an infection due to the food and waterborne trematodes fasciola hepatica and fasciola gigantica, is among the most neglected of the neglected tropical diseases. This food and waterborne disease is a major public health and veterinary issue. A survey was undertaken on the lymnaeid snails inhabiting the hyperendemic area of cajamarca, where human prevalences are the highest known among the areas presenting a valley transmission. A metaanalysis of epidemiological surveys from 38 communities in the region demonstrates that fasciolosis has been endemic in the region since at least 1984 and is a zoonosis of rural communities. The life cycle of these trematodes involves snail as an intermediate host. Fascioliasis is a major parasitic disease caused by the digenetic trematodes fasciola hepatica and fasciola gigantica. Fasciola hepatica is the causative agent of fasciolosis in peru. Molecular characterisation of galba truncatula, lymnaea. Human fascioliasis is a trematode zoonosis of interest in public health. It is difficult to estimate the economic impact of this infection in the human health due to its status of neglected disease, but fasciolosis is hyperendemic in the poorest andean areas of peru where the situation has to be recognized as a public health emergency. Fasciolosis is an important disease caused by the liver flukes fasciola hepatica and f. Association of fasciola hepatica infection with liver.
Fasciolosis is a zoonotic food and waterborne infection related to great economic losses on ruminant production. Author summary fasciola hepatica is a parasite responsible for the zoonotic disease fasciolosis, prevalence of which has increased in recent years because of the emergence of triclabendazoleresistant strains as well as changing climatic conditions. Download fulltext pdf strategic control of fasciolosis in the interandean valley of cajamarca, peru article pdf available in the veterinary record 1432. The disease is a plantborne trematode zoonosis, and is classified as a neglected tropical disease ntd. Download fulltext pdf fasciolosis in south america. The elevation ranges from 162430 mean sea trematodes of the genusfasciola. Valley versus altiplanic patterns analysed in liver flukes from sheep from cajamarca and mantaro, peru, infection, genetics and evolution on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The ectopic involvement is either a result of parasite migration or perhaps eosinophilic reaction. The use of ligasure reduced drainage amount and duration of drain till removal, but increased operative time.
Fasciola hepatica primarily involves the liver, however in some exceptional situations other organs have been reported to be involved. Fascioliasis is the vectorborne parasitic disease presenting the widest latitudinal, longitudinal and altitudinal distribution known at present. Triclabendazole tcbz is the only chemical that kills early immature and adult fasciola hepatica liver fluke but widespread resistance to the drug greatly compromises fluke control in livestock and humans. Due to the high prevalence of tcbz resistance tcbzr, effective management of drug. Claudia machicado, stephane bertani 3, patricia herreravelit. The prevalence of bovine fasciolosis in denmark is increasing but appropriate guidelines for control are currently lacking.
Economic impact of the liver condemnation of cattle. Immune diagnosis of human fasciolosis in children from. Pdf strategic control of fasciolosis in the interandean. A control programme, involving two doses of the fasciolicide triclabendazole aimed at reducing the passage of fasciola hepatica eggs on to the pasture, together with the use of the molluscicide, niclosamide, was evaluated. Endemic human fasciolosis in the bolivian altiplano. Prevalence of fascioliosis in polygastric animals in peru, 19852015. Pdf hyperendemicity of human fasciolosis in the mantaro. The use of ligasure vessel sealing system in axillary. Epidemiology of fascioliasis in human endemic areas.
One of the highest levels of human fasciolosis hepatica is found amongst the indigenous aymaran people of the northern bolivian altiplano. The sstt, described by tello in peru, has been reported as a simple, inexpensive and effective technique for diagnosis of eggs, cysts, larvae and trophozoites of intestinal parasites. Human fasciola hepatica infection in peru is an emerging infectious disease. Leucine aminopeptidase is an immunodominant antigen of.
The first section gives a detailed account of two human cases of hepatic distomatosis produced by fasciola hepatica. Bovine fasciolosis is a parasitic disease of cattle caused by trematodes usually fasciola gigantic and rarely fasciolahepatica in the tropics. Fasciolosis definition of fasciolosis by medical dictionary. Current threat of triclabendazole resistance in fasciola. Fascioliasis due to fasciola hepatica and fasciola. Fasciolosis is recognised as a major problem in dairy cattle in cajamarca, peru. Seroprevalence of human fasciolosis in lorestan province.
Abattoir survey on prevalence of bovine fasciolosis in. The epidemiology of fasciolosis in the interandean valley of cajamarca, peru. Epidemiology of fascioliasis in human endemic areas volume 79 issue 3 s. The objective of present study was to determine the prevalence of natural caprine fasciolosis in the mixteca region of mexico using coproantigen and serum igg1 elisa tests for comparative purposes. Strategic control of fasciolosis in the interandean. A dot in the alignment indicates that the sequence is identical to that of fasciola hepatica from peru lc061151 in fig.
It affects approximately 50 million people worldwide and over 180 million are at risk of infection in both developed and underdeveloped countries. One of the main control measures is the use of anthelmintic drugs, of which tcbz has been one of. Some aspects of bovine fasciolosis in northern gazira and khartoum state. Fasciolosis is a parasitic worm infection caused by the common liver fluke fasciola hepatica as well as by fasciola gigantica. Zoonotic infections are among the most common on earth and are responsible for 60 per cent of all human infectious diseases. High prevalence rates of fascioliasis has been repeatedly reported in the andean region of south america. In order to determine the prevalence of bovine liver condemnations due to fasciolosis in an abattoir at the central andes of peru, we evaluated the records of an authorized slaughterhouse in huancayo, at 3300 m above sea level, over 16 months. Human and animal fascioliasis is emerging in many world regions, among which andean countries constitute the largest regional hot spot and peru the country presenting more human endemic areas. Human fascioliasis hf is a zoonotic disease that has been identified in many countries worldwide. It affects humans, but its main host is ruminants such as cattle and sheep. Acute fasciolosis in cattle in southern brazil 707 results the cows were in a wetland during summer in february 2011 and returned for calving near the facility in august to a paddock with rice stubble. Farmlevel risk factors for fasciola hepatica infection in. In addition to the economic impact inflicted on livestock farmers, fasciolosis is an emergent zoonosis. Some of the most important and wellknown human zoonoses are caused by worm or helminth parasites, including species of nematodes trichinellosis, cestodes cysticercosis, echinococcosis and trematodes schistosomiasis.
In world health organization, water borne zoonosis. Fasciolosis is reemerging as a food borne disease in human populations with outbreaks in bolivia, peru, ecuador, vietnam, thailand, egypt and iran 1,3,4. Seroprevalence of human fasciolosis in a newemerging focus of fasciolosis in yasuj district, southwest of iran. Diagnosis of human fascioliasis in arusha region, northern. Negative serology of fasciola hepatica infection in patients with liver cancer in peru. Genetic diversity of fasciola hepatica in spain and peru. Read fasciola hepatica phenotypic characterization in andean human endemic areas. Bovine fasciolosis is an economically important guduru wollega zone west of addis ababa at a distance parasite disease of cattle caused by fasciollidae family, of 295km.
583 1442 1068 548 1244 539 965 432 687 211 1312 941 1485 1447 64 611 971 1065 455 534 982 513 434 1608 417 1086 1431 722 317 1078 904 1089 492 134